The defeat was the Ligue 1 side’s heaviest in the competition and leaves them with one point from four matches. Thierry Henry’s Monaco are out of the Champions League after they were thrashed by Club Brugge.
Henry, 41, is winless in five games in charge, with this a third defeat. A Hans Vanaken double and a Wesley Moraes strike put Club Brugge 3-0 up at the break, before Ruud Vormer completed the victory late in the second half.
The loss extends Monaco’s run this season to 15 games without a victory in all competitions – they have not won since their second game of the campaign.
Atletico Madrid’s 2-0 victory against Borussia Dortmund in Spain means those two teams have nine points in Group A, while third-placed Club Brugge have four points and retain an outside chance of reaching the knockout stages.